This monograph, authored by Infectious Disease Pharmacist Joanne Huang, highlights key updates from the 2024 ACG guidelines on H. pylori treatment. It covers new recommended therapies, how they work, guidance on medication substitutions, and the role of antibiotic resistance in shaping current treatment strategies. It also briefly addresses considerations for IV therapy in special cases. Read on for a clear breakdown of the latest evidence and practical insights to support clinical decision-making.